HDL-C: Does it matter? An update on novel HDL-directed pharmaco-therapeutic strategies
نویسندگان
چکیده
منابع مشابه
HDL-C: does it matter? An update on novel HDL-directed pharmaco-therapeutic strategies.
It has long been recognized that elevated levels of low-density lipoprotein cholesterol (LDL-C) increase the risk of cardiovascular disease (CHD) and that pharmacologic therapy to decrease LDL-C significantly reduces cardiovascular events. Despite the effectiveness of statins for CHD risk reduction, even optimal LDL-lowering therapy alone fails to avert 60% to 70% of CHD cases. A low plasma con...
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Hydroxy-methyl glutaryl coenzyme A reductase inhibitors (statins) have accumulated an extraordinary record of successful randomized clinical trials, transforming the practice of preventive cardiology. However, most placebo-controlled statin trials have reported not more than 25–35% reduction in morbidity/mortality during 5 year follow-up. Thus, despite their established benefits in primary and ...
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The topic of this article is an important practical lipidologic issue, along with familial hypercholesterolaemia and severe hypertriglyceridaemia which have also been recently reviewed in the Polish literature. In this paper, we attempted to summarise current scientific evidence and views on the complex role of HDL in atherogenesis, as well as therapeutic recommendations in patients with low HD...
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ژورنال
عنوان ژورنال: International Journal of Cardiology
سال: 2013
ISSN: 0167-5273
DOI: 10.1016/j.ijcard.2012.05.052